By Robert B. Stewart, Larry A. Grupp (auth.), Alan A. Boulton, Glen B. Baker, Peter H. Wu (eds.)
to the Animal versions Volumes This quantity describes animal types of drug habit. due to expanding public predicament over the moral therapy of animals in study, we felt it incumbent upon us to incorporate this common preface so that it will point out why we predict additional examine utilizing animals is critical. Animals should still merely be used while compatible possible choices usually are not on hand, and people can merely be experimented upon in significantly proscribed conditions. substitute techniques utilizing phone or tissue tradition are insufficient in any types requiring checks of behavioral swap or of complicated in vivo p- cesses. despite the fact that, whilst the misery, pain, or discomfort to the animals outweighs the expected profits for human welfare, the examine isn't moral and shouldn't be performed. it truly is relevant that every person researcher learn his/ her personal study from a severe ethical point of view sooner than eng- ing in it, and think about the animals’ welfare in addition to the predicted earnings. moreover, as soon as a choice to p- ceed with examine is made, it's the researcher’s accountability to make sure that the animals’ welfare is of top problem by way of acceptable housing, feeding, and greatest relief of any uncomfortable or distressing results of the experimental conditions.
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Additional info for Animal Models of Drug Addiction
Q 1. Stud. Alcohol 34,769-773. Dahl L. , and Tassinari L. (1962) Effects of chronic salt ingestion. J. Exp. Med. 115,1173-1190. Deitrich R. A. and Melchior C. L. (1985) A critical assessment of animal models for testing new drugs for altering ethanol intake, in Research Advances in New Psychopharmacological Treatments for Alcoholism , Naranjo C. A. and Sellers E. ), Excerpta Medicu, Amsterdam, pp. 2343. , and Seever M. H. (1969) Self-administration of psychoactive substances by the monkey. ) 16, 30-84.
M. (1984) Absence of reinforcement with low dose intravenous ethanol self-administration in rats. Phamacol. 21,609-615. Oei T. P. S. and Singer G. (1979) Effects of a fixed time schedule and body weight on ethanol self-administration. 10, 767-770. Pfeffer A. 0. and Samson H. H. (1985) Oral ethanol reinforcement in the rat: Effects of acute amphetamine. Alcohol 2,693-697. Pine1 J. P. J and Huang E. (1976) Effects of periodic withdrawal on ethanol and saccharin selection in rats. 16,693-698. Richter C.
They found that the polydipsia procedure was not as effective with full-weight rats and with liquid food reinforcers rather than dry food pellets. Only about half of their animals were induced to consume ethanol, in contrast with an almost 100% success rate for weight-reduced rats indicated in the lit- Alcohol Consumption Models 17 erature. , 1972). Along similar lines, Stewart et al. (1988) attempted to train rats that were not weightreduced to self-administer ethanol using the prandial drinking method.
Animal Models of Drug Addiction by Robert B. Stewart, Larry A. Grupp (auth.), Alan A. Boulton, Glen B. Baker, Peter H. Wu (eds.)